The strategy that I am most aligned with in people's minds is the idea of drafting back-to-back quarterbacks. I've written about it many times and I want to underscore it again here.
It is true that an elite QB can give you an edge. I'd love to have Aaron Rodgers. It's just not going to happen. Those first 6 (or more) rounds have to be dedicated to the scarcest of resources and the second-scarcest of resources... Those being stud running backs and difference-maker wide receivers, respectively.
The early round quarterback has mostly disappeared from the fantasy landscape but in my opinion it's just as bad, probably worse, to take one guy in the middle rounds and bank on him being your starter all year. See, more than any other position (besides DST, I suppose), quarterback is highly matchup-dependent. You know going in to a week what kind of matchup your guy has. You also know that in your bye week you'll need a waiver wire guy.
Ahh, waiver wire. Streaming QB's isn't the worst idea in the world, particularly since it frees up bench spots and draft capital for those aforementioned scarce resources. But, let's take a look at what you're really doing here. Let's say that in a 12-team league there are 20 QB's rostered. In my experience that's actually pretty conservative. So, at best you'll be picking amongst QB's #21 through #32 to find a usable matchup for that week. Hit and miss.
In my strategy, you wait until you are around the 10th team to draft a QB and then you go back-to-back. You'll have something like QB10 and QB11, both with upside... and you'll cover your bye weeks... plus injury insurance. But the best part? You play the matchups since they're interchangeable. Most weeks you'll have at least one strong option.
It does cost you two roster spots, but instead of taking Rodgers in the 3rd or 4th round you get another stud RB. That's better than the RB's you would have taken in the 9th or 10th round. Besides, your combo has a great chance to combine for stats comparable to QB4 or QB3. Matchups, baby.